Reduced paresthesia with DRG vs SCS stimulation for chronic pain

Study finds dorsal root ganglion stimulation produces less paresthesia (i.e. pins-and-needles sensation) than spinal cord stimulation when used to treat chronic pain.

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category: Pain and Other Related Topics

Ambroxol: a potential new treatment for chronic pain

Studies find that a drug used in cough syrup and cold medicines could be used topically to treat neuropathic pain.

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category: Pain and Other Related Topics

Poor functional outcomes in pediatric chronic pain – what’s catastrophizing got to do with it?

Analysis of existing studies of pediatric chronic pain patients finds that catastrophizing produced a strong relationship with anxiety, depression, and quality of life, as well as a moderate relationship with physical functioning and pain intensity.

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category: Pain and Other Related Topics

Hormones & pain care: what every patient should know

Researchers identify hormones that may benefit chronic pain patients.

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category: Pain and Other Related Topics

Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the International Classification of Diseases (ICD-11)

International Association for the Study of Pain develops classification system for subgroups of chronic pain.

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category: Pain and Other Related Topics

Self-management of chronic pain in primary care

Discussion of the challenges faced by primary care providers in treating chronic pain and the need for more effective self-management strategies.

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category: Pain and Other Related Topics

MR Neurography: using peripheral nerve imaging as a pain diagnostic

Q&A with radiology specialists on using magnetic resonance neurography to diagnose peripheral nerve pain.

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category: Pain and Other Related Topics

Pain relief in a neuropathy patient by lacosamide: Proof of principle of clinical translation from patient-specific iPS cell-derived nociceptors

Stem cell technology was used to identify personalized treatment for a patient with small fiber neuropathy.

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category: Pain and Other Related Topics

Cyclosporine-induced erythromelalgia

Case report of a 56-year-old female with secondary EM triggered by oral cyclosporine.

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category: General EM

Pain management in children with erythromelalgia: case report

Case report of a 9-year-old girl treated with carbamazepine.

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category: Treatment

Current pain management strategies for patients with erythromelalgia: a critical review

Comprehensive review of literature on treatment approaches for EM.

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category: Treatment

Genetic studies of human neuropathic pain conditions: a review

Comprehensive review of studies on neuropathic pain conditions provides an overview of genetic variants implicated.

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category: Pain and Other Related Topics

Trial & Error for Treating Erythromelalgia

Discussion of EM treatment options, using approach based on drug’s mechanism of action.

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category: Treatment

Erythromelalgia: a cutaneous manifestation of neuropathy?

Discussion covering all aspects of EM.

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category: General EM

What you need to know about chilblains

Explanation of all aspects of chilblains (pernio), including symptoms, causes, and treatments.

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category: Pain and Other Related Topics

Could systemic lidocaine be the new standard of care for pain due to inflammation?

Intravenous lidocaine found to be effective in preventing and relieving chronic inflammatory and neuropathic pain.

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category: Pain and Other Related Topics

Some patients with erythromelalgia respond well to corticosteroids

Mayo Clinic study finds corticosteroids most effective when EM is caused by surgery or trauma, when onset is rapid, and when patient is treated promptly.

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category: Treatment

Localized neuropathic pain: an expert consensus on local treatments

Comprehensive review of literature on localized neuropathic pain and existing topical medications, identifying 5% lidocaine patch (Lidoderm/Versatis) and 8% capsaicin patch (Qutenza) as proven first-line treatments.

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category: Pain and Other Related Topics

Intermittent Signs of Erythromelalgia Diagnosed by Smartphone Selfie

Case report of a 42-year-old Japanese woman whose smartphone pictures helped doctors reach a diagnosis of EM.

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category: General EM

Resolution of primary erythromelalgia following ibuprofen; Fire power

Case report of a 6-year-old girl treated with ibuprofen.

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category: Treatment

Burning pain: axonal dysfunction in erythromelalgia

Study of 23 EM patients demonstrates dysfunction in peripheral nerve axons.

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category: Research

Complex management of a patient with refractory primary erythromelalgia lacking a SCN9A mutation

Case report of a 41-year-old female treated with a number of different drug therapies.

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category: Treatment

Erythromelalgia: identification of a corticosteroid-responsive subset

Mayo Clinic study finds corticosteroids most effective when EM is caused by surgery or trauma, when onset is rapid, and when patient is treated promptly.

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category: Treatment

The challenging task of erythromelalgia therapy

Discussion of EM treatment options.

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category: Treatment

Erythromelalgia in the pediatric patient: role of computed tomography-guided lumbar sympathetic blockade

Case reports of three juveniles treated with a block of the lumbar sympathetic nerves.

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category: Treatment

Advanced genetic testing comes to the Pain Clinic to make a diagnosis of paroxysmal extreme pain disorder

Next-generation sequencing technology used at Mayo Clinic, Jacksonville, FL, to identify gain of function SCN9A mutation in a patient with symptoms of paroxysmal extreme pain disorder.

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category: Pain and Other Related Topics

No pain and extreme pain from one gene

Different mutations in the SCN9A gene are found to cause complete absence of pain or acute pain of EM.

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category: General EM

Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia

Pfizer study of five EM patients treated with sodium channel Nav1.7-blocker; drug was also tested on sensory neurons derived from patients’ stem cells.

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category: Research

Pharmacotherapy for Pain in a Family With Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling

Study demonstrates that drug therapy guided by genomic analysis and functional profiling can reduce neuropathic pain in patients with a sodium channel Nav1.7 mutation.

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category: Research

Understanding atomic interactions to achieve well-being  

Explanation of the underlying molecular mechanism of sodium channels, in reference to article “Pharmacotherapy for pain in a family with inherited EM.”

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category: Research

Topically applied midodrine, 0.2%, an α1-agonist, for the treatment of erythromelalgia

Mayo Clinic study of 12 EM patients treated with topical midodrine cream.

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category: Treatment

A large temperature fluctuation may trigger an epidemic erythromelalgia outbreak in China

Retrospective study explores possible association between temperature fluctuation during winter months and epidemic EM outbreaks in China, mainly occurring in adolescent females.

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category: General EM

Erythromelalgia mutation Q875E stabilizes the activated state of sodium channel Nav1.7

Study establishes characteristics of one sodium channel Nav1.7 mutation.

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category: Research

Mutations in sodium channel gene SCN9A and the pain perception disorders

The role of SCN9A gene mutations in three pain perception disorders, including EM.

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category: Research

Dual effect of ziconotide in primary erythromelalgia

Case report of a 31-year-old female treated with ziconotide administered intrathecally into the spinal canal. 

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category: Treatment

A case of erythromelalgia: good response to combination treatment with pregabalin and selective serotonin reuptake inhibitor

Case report of a 45-year-old female with secondary EM treated with pregabalin and sertraline.

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category: Treatment

Facial erythromelalgia: a rare entity to consider in the differential diagnosis of connective tissue diseases

Case report of a 53-year-old male with facial EM demonstrates that EM can be mistaken for connective tissue disease.

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category: General EM

Mexiletine as a treatment for primary erythromelalgia: normalization of biophysical properties of mutant L858F Nav1.7 sodium channels

Study investigates the effects of mexiletine on one sodium channel Nav1.7 mutation.

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category: Research

Therapeutic success with local botulinum toxin in erythromelalgia

Case report of a 31-year-old female treated with Botox.

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category: Treatment

A new TRPV3 missense mutation in a patient with Olmsted syndrome and erythromelalgia

Case report of a young girl whose EM is associated with the rare keratinizing disorder Olmsted syndrome.

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category: General EM

An Egyptian child with erythromelalgia responding to a new line of treatment: a case report and review of the literature

Case report of a 3-year-old boy treated with Zyrtec.

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category: Treatment

Human pain and genetics: some basics

Recent advances in genetics have revealed that subtle changes in DNA could explain individual differences in pain sensitivity and perception.

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category: General EM

Secondary erythromelalgia—a case report

Case report of a 48-year-old female with secondary EM linked to essential thrombocythemia.

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category: General EM

Effectiveness of botulinum toxin A in treatment of refractory erythromelalgia

Case report of a 58-year-old female treated with Botox.

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category: Treatment

Evidence of small-fiber polyneuropathy in unexplained, juvenile-onset, widespread pain syndromes

Study finds small-fiber polyneuropathy prevalent in young patients with unexplained pain.

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category: Pain and Other Related Topics

Topical amitriptyline combined with ketamine for the treatment of erythromelalgia: a retrospective study of 36 patients at Mayo Clinic

Retrospective study of 36 EM patients treated with topical amitriptyline/ketamine cream.

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category: Treatment

A novel SCN9A mutation responsible for primary erythromelalgia and is resistant to the treatment of sodium channel blockers

Study identifies a new sodium channel Nav1.7 mutation that appears resistant to lidocaine and mexiletine.

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category: Research

Erythromelalgia? A clinical study of people who experience red, hot, painful feet in the community

New Zealand study finds that the incidence of EM may be greater than commonly accepted.

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category: General EM

The red ear syndrome

Discussion of red ear syndrome, a possible variant of EM.

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category: General EM

Biorhythms and erythromelalgia: why EM symptoms worsen in the evening and at night

Explanation of the autonomic nervous system and its effects on the timing of EM symptoms.

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category: General EM

The Nav1.7 sodium channel: from molecule to man

Genetic and functional studies add to the evidence that sodium channel Nav1.7 is a major contributor to pain signaling in humans.

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category: Research

Paediatric hypertension-associated erythromelalgia responds to corticosteroids and is not associated with SCN9A mutations

Case report of a 9-year-old boy treated with corticosteroids.

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category: Treatment

Successful treatment of adult-onset erythromelalgia with steroid pulse and pregabalin

Case report of a 68-year-old female treated with corticosteroids and pregabalin.

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category: Treatment

Sodium channel Nav1.7 is essential for lowering heat pain threshold after burn injury

Yale study finds that sodium channel Nav1.7 is responsible for the burning pain felt after burn injuries.

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category: Research

Results of computer-assisted sensory evaluation in 41 patients with erythromelalgia

Mayo Clinic review of 41 EM patients and their quantitative sensory testing results.

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category: Research

Severe case and literature review of primary erythromelalgia: novel SCN9A gene mutation

Study identifies a new sodium channel Nav1.7 mutation in a 15-year-old girl with severe, progressive EM.

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category: Research

Supplements and herbs in the treatment of erythromelalgia

Summary of supplements used to treat EM.

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category: Treatment

What is erythromelalgia?

Discussion of EM and a possible underlying cause.

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category: General EM

Gain of function Naν1.7 mutations in idiopathic small fiber neuropathy

Study of 28 patients with unexplained small fiber neuropathy finds SCN9A gene mutations to be the cause.

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category: Research

The medical treatment of erythromelalgia

Summary of EM treatment options.

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category: Treatment

Erythromelalgia: an uncommon presentation precipitated by aspirin withdrawal

Case report of a 64-year-old female with secondary EM triggered by aspirin withdrawal.

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category: General EM

Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch

Discussion of high-concentration 8% capsaicin patch (Qutenza) for treating neuropathic pain.

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category: Treatment

Refractory erythromelalgia of the ears: response to mexiletine

Case report of a 58-year-old male treated with mexiletine.

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category: Treatment

Massage therapy techniques as pain management for erythromelalgia: a case report

Case report of a 31-year-old female treated with massage therapy. 

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category: Treatment

Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Nav1.7 produce distinct pain disorders

Study compares properties of different sodium channel Nav1.7 mutations that result in two separate pain conditions.

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category: Research

Can robots patch-clamp as well as humans? Characterization of a novel sodium channel mutation

Researchers compare a patch-clamp robot with human patch-clamp in a functional assessment of a sodium channel Nav1.7 mutation linked to EM.

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category: Research

Sodium channels in normal and pathological pain

Explanation of the molecular mechanism of four sodium channel subunits and their role in neuropathic and inflammatory pain.

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category: Research

Erythromelalgia mutation L823R shifts activation and inactivation of threshold sodium channel Nav1.7 to hyperpolarized potentials

Study establishes characteristics of one sodium channel Nav1.7 mutation.

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category: Research

A sodium channel gene SCN9A polymorphism that increases nociceptor excitability

Study of a family with inherited EM suggests that variants in sodium channel Nav1.7 may influence susceptibility to pain.

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category: Research

Experience with oral mexiletine in primary erythromelalgia in children

Case reports of two juveniles treated with oral mexiletine.

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category: Treatment

Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation

Study compares gene mutations related to early- and late-onset inherited EM; late-onset EM is associated with less severe symptoms.

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category: Research

A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia

Study finds a newly identified sodium channel Nav1.7 mutation to be uniquely responsive to carbamazepine.

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category: Research

Mexiletine-responsive erythromelalgia due to a new Nav1.7 mutation showing use-dependent current fall-off

Study finds a newly identified sodium channel Nav1.7 mutation to be uniquely responsive to mexiletine.

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category: Research

Incidence of erythromelalgia: a population-based study in Olmsted County, Minnesota

Mayo Clinic study estimates the incidence of EM at 1.3 per 100,000 people per year.

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category: General EM

Intervention for erythromelalgia, a chronic pain syndrome: comprehensive pain rehabilitation center, Mayo Clinic

Retrospective study of eight EM patients admitted to Mayo Clinic’s pain rehabilitation program.

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category: Treatment

Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas

Study of patients with painful neuromas finds that increased expression of certain sodium channels, including Nav1.7, contributes to pain following nerve injury.

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category: Research

A patient with adult erythermalgia: evidence suggesting an autoimmune etiology

Case report of a 64-year-old female with secondary EM linked to thrombocytopenia.

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category: General EM

Mexiletine therapy for chronic pain

Study of 37 neuropathic pain patients finds that intravenous lidocaine may predict responsiveness to oral mexiletine.

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category: Pain and Other Related Topics

Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders

The role of sodium channel Nav1.7 mutations in three pain disorders, including EM.

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category: Research

A Nav1.7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity

Study links one sodium channel Nav1.7 mutation to reduced responsiveness to lidocaine.

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category: Research

Melatonin the “light of night” in human biology and adolescent idiopathic scoliosis

Melatonin’s role in circadian rhythms and other biological functions; studies look for link between the hormone and scoliosis.

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category: Pain and Other Related Topics

A case of inherited erythromelalgia

Study identifies a sodium channel Nav1.7 mutation in a 15-year-old boy with inherited EM.

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category: Research

Defining a treatable cause of erythromelalgia: acute adolescent autoimmune small-fiber axonopathy

Case report of a 20-year-old male treated with corticosteroids and intravenous lidocaine infusion.

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category: Treatment

Temperature dependence of erythromelalgia mutation L858F in sodium channel Nav1.7

Study tests the effects of temperature on a sodium channel Nav1.7 mutation.

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category: Research

Neurobiology: a channel sets the gain on pain

Different mutations of sodium channel Nav1.7 can trigger intense pain of EM or prevent all pain sensation.

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category: Research

Thermoregulatory sweat testing in patients with erythromelalgia

Retrospective study of 32 EM patients finds small-fiber neuropathy and absence of sweating prevalent.

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category: Research

Erythromelalgia: a case report and literature review

Case report of a 44-year-old male; general discussion of diagnostic testing, treatment options, and prognosis.

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category: General EM

Histopathologic findings in primary erythromelalgia are nonspecific: special studies show a decrease in small nerve fiber density

Skin biopsies from 29 EM patients show a decrease in small nerve fiber density.

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category: Research

Erythromelalgia: an underrecognized manifestation of small-fibre neuropathy

Case report of a 43-year-old female suggests that EM is a form of small-fiber neuropathy.

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category: General EM

A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons

A sodium channel Nav1.7 mutation renders sensory neurons hyperexcitable and sympathetic neurons hypoexcitable.

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category: Research

Erythromelalgia

Discussion of EM treatments and lifestyle modifications.

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category: Treatment

Combination gel of 1% amitriptyline and 0.5% ketamine to treat refractory erythromelalgia pain: a new treatment option?

Case report of a 17-year-old female treated with topical amitriptyline/ketamine gel.

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category: Treatment

Pregabalin and gabapentin for neuropathic pain and CRPS/RSD

Comparison of pregabalin and gabapentin for neuropathic pain relief.

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category: Treatment

Autosomal dominant erythermalgia associated with a novel mutation in the voltage-gated sodium channel alpha subunit Nav1.7

Study identifies a new sodium channel Nav1.7 mutation in a family with inherited EM.

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category: Research

Lidocaine patch for pain of erythromelalgia: follow-up of 34 patients

Study of 34 EM patients treated with lidocaine patch.

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category: Treatment

Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons

Study identifies a new sodium channel Nav1.7 mutation in a family with inherited EM.

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category: Research

Genetic heterogeneity and exclusion of a modifying locus at 2q in a family with autosomal dominant primary erythermalgia

Study tests a family with inherited EM for genetic linkage to chromosome 2q, as well as for variants in the SCN9A gene.

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category: Research

SCN9A mutations define primary erythermalgia as a neuropathic disorder of voltage gated sodium channels

Study identifies multiple sodium channel Nav1.7 mutations in four families with inherited EM.

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category: Research

Erythromelalgia: a hereditary pain syndrome enters the molecular era

EM is the first human disorder in which it has been possible to associate an ion channel mutation with chronic neuropathic pain.

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category: Research

Primary Erythromelalgia in a Child Responding to Intravenous Lidocaine and Oral Mexiletine Treatment.

Case report of an 11-year-old boy treated with intravenous lidocaine infusion and oral mexiletine.

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category: Treatment

A refractory case of erythromelalgia involving the ears

Case report of a 53-year-old male who remained resistant to all treatment.

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category: General EM

Alleviation of erythromelalgia with venlafaxine

Case report of a 58-year-old female treated with venlafaxine.

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category: Treatment

Coexistence of erythromelalgia and Raynaud’s phenomenon

Case report of a 42-year-old female with both Raynaud’s and EM, and discussion of the association between the two conditions.

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category: EM/Raynaud's

The prostaglandin E1 analog misoprostol reduces symptoms and microvascular shunting in erythromelalgia – a double-blind, crossover, placebo-compared study

Study of 21 EM patients treated with misoprostol.

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category: Treatment

Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia

Study identifies two sodium channel Nav1.7 mutations in a Chinese family.

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category: Research

Erythromelalgia: vasculopathy, neuropathy, or both? A prospective study of vascular and neurophysiologic studies in erythromelalgia

Mayo Clinic study of 67 EM patients finds most to have small-fiber neuropathy.

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category: Research

Treatment of primary erythromelalgia with cyclosporine

Case report of a 28-year-old female with inherited EM treated with cyclosporine.

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category: Treatment

Skin blood flow in adult human thermoregulation: how it works, when it does not, and why

Explanation of the autonomic and local mechanisms of skin blood flow and temperature regulation.

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category: General EM

Erythromelalgia induced by possible calcium channel blockade by ciclosporin

Case report of a 37-year-old male with secondary EM triggered by ciclosporin.

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category: General EM

Serotonin reuptake inhibitors, Raynaud’s phenomenon and erythromelalgia

Case reports of two adults who developed EM symptoms after being treated for Raynaud’s with sertraline and fluoxetine.

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category: EM/Raynaud's

Pathological C-fibres in patients with a chronic painful condition

Study finds slower nerve conduction and hyperexcitable nerve fibers in EM patients.

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category: Research

Aspirin-responsive painful red, black toe, or finger syndrome in polycythemia vera associated with thrombocythemia

Case report of five thrombocythemia patients with EM symptoms treated with aspirin.

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category: Treatment

Prostacyclin reduces symptoms and sympathetic dysfunction in erythromelalgia in a double-blind randomized pilot study

Study of 12 EM patients treated with iloprost.

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category: Treatment

Red skin re-read

Summary of findings by Mørk and Kvernebo: the increased blood flow of EM may be caused by shunting of blood away from capillaries.

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category: Research

Reduced skin capillary density during attacks of erythromelalgia implies arteriovenous shunting as pathogenetic mechanism

Study of 14 EM patients finds reduced skin capillary density.

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category: Research

Erythromelalgia: an endothelial disorder responsive to sodium nitroprusside

Case reports of two juveniles treated with sodium nitroprusside infusion.

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category: Treatment

Impaired neurogenic control of skin perfusion in erythromelalgia

Study of 14 EM patients finds sympathetic nerve dysfunction associated with abnormal skin blood flow.

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category: Research

Treatment of erythromelalgia with a serotonin/noradrenaline reuptake inhibitor

Study of ten EM patients treated with venlafaxine.

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category: Treatment

Lidocaine patch for pain of erythromelalgia

Case report of a 15-year-old girl treated with lidocaine patch.

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category: Treatment

Treatment of Raynaud’s phenomenon with the selective serotonin reuptake inhibitor fluoxetine.

Study of 53 Raynaud’s patients treated with fluoxetine or nifedipine.

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category: EM/Raynaud's

Resolution of refractory symptoms of secondary erythermalgia with intermittent epidural bupivacaine

Case report of a 28-year-old female with secondary EM treated with epidural bupivacaine.

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category: Treatment

Unexpected healing of cutaneous ulcers in a short child

Case report of a 12-year-old boy treated with growth hormone.

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category: Treatment

Hot feet: erythromelalgia and related disorders

Over-sensitization of small nerve fibers may be one possible cause of EM.

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category: General EM

Erythromelalgia: new theories and new therapies

Review of successful treatments, based on TEA’s member survey.

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category: Treatment

Microvascular arteriovenous shunting is a probable pathogenetic mechanism in erythromelalgia

Study tests 14 EM patients for abnormal skin blood flow.

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category: Research

Functional link between distal vasodilation and sleep-onset latency?

Study demonstrates connection between sleep onset, core body temperature, and vasodilation of the extremities.

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category: Pain and Other Related Topics

Natural history of erythromelalgia: presentation and outcome in 168 patients

Review of 168 EM patients seen at Mayo Clinic from 1970 to 1994.

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category: General EM

Treatment of refractory primary erythromelalgia in a child using a continuous epidural infusion

Case report of a 4-year-old boy treated with bupivacaine/clonidine epidural.

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category: Treatment

Lidocaine and mexiletine therapy for erythromelalgia

Case report of a 25-year-old male treated with intravenous lidocaine infusion and oral mexiletine.

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category: Treatment

Skin perfusion in patients with erythromelalgia

Study of 61 EM patients finds vasoconstriction prevalent.

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category: Research

Impaired skin vasomotor reflexes in patients with erythromelalgia

Study shows that EM patients have diminished sympathetic vasoconstrictor responses.

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category: Research

Erythromelalgia – A condition caused by microvascular arteriovenous shunting

Discussion covering all aspects of EM, in particular its connection to abnormal skin blood flow.

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category: General EM

Erythromelalgia: response to serotonin reuptake inhibitors

Case reports of three adults treated with venlafaxine or sertraline.

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category: Treatment

Nitroprusside treatment of erythromelalgia in an adolescent female

Case report of a 15-year-old girl treated with sodium nitroprusside infusion.

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category: Treatment

Erythromelalgia pain managed with gabapentin

Case reports of one child and one adult treated with gabapentin.

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category: Treatment

Nature and mechanism of peripheral nerve damage in an experimental model of non-freezing cold injury

Study demonstrates that prolonged exposure to cold causes peripheral nerve damage.

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category: Pain and Other Related Topics

Refractory idiopathic erythromelalgia

Case reports of two adolescent males treated with epidural analgesia.

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category: Treatment

Temperature-associated vascular disorders: Raynaud’s phenomenon and erythromelalgia

Excerpt covering all aspects of EM and Raynaud’s, including cause, diagnosis, and treatments.

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category: EM/Raynaud's

The use of capsaicin cream in a case of erythromelalgia

Case report of a 68-year-old female treated with topical capsaicin cream.

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category: Treatment

Fighting pain with fire: hot chili peppers offer relief

Discussion of capsaicin for treating neuropathic pain.

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category: Treatment

Erythromelalgia and erythermalgia: diagnostic differentiation

Classification of three EM subtypes as separate disorders, and discussion of their causes.

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category: General EM

Autosomal dominant erythromelalgia

Case report of an Alabama family with inherited EM.

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category: General EM

Erythromelalgia—the role of hypnotherapy

Case report of an 18-year-old female treated with hypnotherapy.

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category: Treatment

Erythromelalgia: symptom or syndrome?

Discussion covering all aspects of EM, including treatment for different subtypes.

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category: General EM

Coexistence of Raynaud’s syndrome and erythromelalgia

Case report of a 40-year-old female with both Raynaud’s and EM; subsequent discussion of the association between the two conditions.

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category: EM/Raynaud's

Poxviruses isolated from epidemic erythromelalgia in China

Report of EM epidemic associated with a viral respiratory infection.

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category: General EM

A way to understand erythromelalgia

Discussion of EM symptoms and treatment with lumbar sympathetic nerve blocks.

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category: Treatment

Erythromelalgia caused by platelet-mediated arteriolar inflammation and thrombosis in thrombocythemia

Report of thrombocythemia patients presenting with EM symptoms.

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category: General EM

Erythromelalgia—a case for biofeedback

Case report of a female EM patient treated with biofeedback.

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category: Treatment